This study examined the effects of misregistration on electrode position in deep brain stimulation (DBS) by using the AFIDs framework to measure registration accuracy in patient scans. AFID registration errors (AFREs) revealed spatial patterns of misregistration that accounted for 28% of the variance in electrode position, highlighting AFIDs as a valuable tool for assessing registration accuracy, quality control, and optimization in DBS research.

This study examined the topographic organization of the zona incerta (ZI) using in vivo diffusion MRI and data-driven connectivity. The findings revealed a rostral-caudal gradient, with the rostral ZI connecting to prefrontal regions and the caudal ZI connecting to sensorimotor cortices, as well as a central ZI region linked to the dorsal prefrontal cortex. These results, replicated across datasets and individuals, provide insights into the ZI’s role in motor, cognitive, and emotional control, with implications for refining neuromodulatory targets.

This study disentangles the what and how components of sequence learning in one experimental paradigm. We confirm that when sequence items are unknown, most learning is learning what to do. However, when the sequence items are known from the beginning, practice still leads to improvements that are effector-specific and generalizable to other sequences.

Recent advances in artificial intelligence provide opportunities to automate the capture and representation of complex features of human language, potentially improving the efficiency of language assessment. This review presents computerized approaches for analyzing narrative language and identifying language disorders in children, highlighting key methods, challenges, and implications for clinical practice.

This study examined whether learning sign language influences visual perception by comparing bimodal bilinguals (hearing signers) and hearing non-signers on face matching and motion discrimination tasks. While no group differences were found, higher ASL proficiency predicted better motion perception, suggesting that linguistic experience may shape visual processing in specific ways.

Sensory expectations influence movement preparation, as humans and monkeys probabilistically cued about a future mechanical perturbation adjust their preparatory activity and improve corrective responses. High-density neural recordings reveal that these expectations shape motor cortical dynamics, with neural population activity scaling with perturbation probability and driving rapid responses through learned sensory-feedback integration.

This study shows that targeted loss of the ATRX chromatin remodeler in microglia alters chromatin accessibility profiles, leading to the de-repression of endogenous retroelements, triggering viral mimicry. Functionally, we find that ATRX microglial deficiency alters the electrophysiological properties of hippocampal neurons and causes deficits in object recognition and spatial memory.

This study systematically evaluates AudioDome capabilities at the Western Interdisciplinary Research Building, assessing the strengths and limitations of its sound reproduction technologies for research applications. The findings presented in this manuscript offer critical insights into the methodological validity of the AudioDome, providing WIN researchers with a foundational framework for its effective use in experimentation.